Although there have been more than 69 drugs in 15 different classes of antihypertensive drugs, such as calcium antagonists, angiotensin-converting enzyme inhibitors, β-adrenoceptor antagonists, diuretics, and direct-acting vasodilators, many more hypertensive patients have resistant hypertension or are uncontrolled for nonadherence or intolerance to available antihypertensive agents (Oparil and Schmieder, 2015). This evidence concerns the gene ACE and hypertensive disorder.