In the status of tumor microenvironment, the activation of canonical Wnt signaling pathway inhibits the phosphorylation of β-catenin and leads to the accumulation of β-catenin in the nucleus, which activates the downstream genes such as cyclin D1 and c-Myc and give rise to the malignant transformation and excessive proliferation (Zhan et al., 2017). This evidence concerns the gene CCND1 and neoplasm.