Notably, aberrant activation of Wnt signaling is frequently observed in human CRC, and a comprehensive genome-scale analysis found that 93% CRC patients carrying loss-of-function mutations in 16 different genes of the Wnt signaling pathway such as biallelic inactivation of the negative regulator adenomatous polyposis coli or activating mutations of β-catenin (Cancer Genome Atlas Network, 2012). The gene discussed is APC; the disease is colorectal carcinoma.