CASP3 and colorectal carcinoma: Simultaneously, the mRNA levels of proapoptotic genes such as BAX, CASP3, CDKN1B, FAS, and TP53 were all downregulated in Wnt3-pEX4 cells after the treatment of cisplatin (Supplementary Figure 4A), indicating a decrease in drug sensitivity when Wnt3 is overexpressed in CRC cells.