A lot of studies have indicated that exercise can enhance the DA use efficiency (Kim et al., 2014) or regulate presynaptic DA transporter and postsynaptic DA receptor (Rui et al., 2013), suggesting that exercise intervention’s efficacy in alleviating PD symptoms may involve other regulatory pathways or neurotransmitters more than the dopaminergic system. The gene discussed is SLC6A3; the disease is Parkinson disease.