At the mRNA level, compared with the control group, the striatal mGluR3 mRNA expression level of the PD group significantly declined, with statistically significant differences (P < 0.01); compared with the PD group, the striatal mGluR3 mRNA expression level of the PD + exercise group was significantly increased, with statistically significant differences (P < 0.01). The gene discussed is GRM3; the disease is Parkinson disease.