Similar phenomenon of TNF-α induced potentiation of Ca2+ current evoked by TRPV1 has been reported in rat pulmonary sensory neurons in asthma (Hu et al., 2010), in cultured trigeminal ganglions isolated from neonatal rats (Meng et al., 2016), in human synoviocytes (Kochukov et al., 2009) and in sensitization of the spinal cord in the pain model (Spicarova and Palecek, 2010). Here, TNF is linked to asthma.