MAPT and Alzheimer disease: As MT reduction in AD and aging is independent of Tau filament formation (Cash et al., 2003), our studies implicate a paucity/dysregulation of EB-interacting endogenous proteins, like ADNP (Oz et al., 2014; Malishkevich et al., 2016) as a contributing mechanism and further provides hope with SKIP-containing drug candidates in future in vivo studies.