Animal studies with mice expressing Adnp from only one allele (Adnp±) have shown that Adnp deficiency is associated with age-dependent neurodegeneration and cognitive impairment, coupled with tauopathy-like features such as an increase formation of tangle-like structures, defective axonal transport, and Tau hyperphosphorylation (Vulih-Shultzman et al., 2007). Here, MAPT is linked to tauopathy.