Increasing evidences showed diabetes shared some common pathogenic mechanisms with AD such as metabolic abnormalities, endoplasmic reticulum (ER) stress, and impaired insulin signaling [e.g., phosphatidylinositol 3 kinase (PI3K)-glycogen synthase kinase 3β (GSK3β) signaling; Kuljiš and Salković-Petrišić, 2011; Blázquez et al., 2014; Fernando et al., 2017; Vieira et al., 2018]. Here, INS is linked to Alzheimer disease.