Further studies confirmed that APP-tg mouse brain extracts were equally efficient to seed Aβ aggregation in APP-tg mice as the ones prepared from human AD brains (Meyer-Luehmann et al., 2006; Eisele et al., 2009; Watts et al., 2011; Morales et al., 2012; Rosen et al., 2012). This evidence concerns the gene APP and Alzheimer disease.