For instance, SNHG16 expression levels were significantly upregulated in osteosarcoma [15], glioma [20, 21], colorectal adenocarcinoma [27], breast cancer [23], cervical cancer [26], ovarian cancer [24], bladder cancer [17, 18], ESCC [19, 28], NSCLC [11], oral squamous cell carcinoma [13], and acute lymphoblastic leukemia [53], but downregulated in HCC [22]. The gene discussed is SNHG16; the disease is central nervous system cancer.