In a previous study, it was also found that certain activated DC2s are able to initiate antitumor immunoreactions.27 It was verified that tumor‐infiltrating DC2s are mostly immature and predominantly serve an immunosuppressive/tolerogenic purpose.28 In our study, patients with N1‐N3 stage gastric cancer had higher tumor‐infiltrating DC2 levels, while patients with T3‐T4 stage gastric cancer showed a lower ratio of tumor‐infiltrating DC1/DC2s. This evidence concerns the gene ZDHHC4 and gastric cancer.