This gene was found to act as a tumour suppressor and to possess highly conserved expression in multiple tissues.9, 10 The expression levels of lncRNA MEG3 were down‐regulated in various types of human tumours, contributing to increase cellular apoptosis via the regulation of p53 protein, microRNA‐127 and microRNA‐21‐5p.11, 12, 13 With regard to the cardiovascular system, the knockdown of lncRNA MEG3 could alleviate hypoxia‐induced H9c2 cell injury.14 However, the role and underlying mechanism of lncRNA MEG3 in MI remain unclear. Here, MEG3 is linked to neoplasm.