BRCA2 and prostate cancer: Prostate cancer is the most frequent cancer in men and the second leading cause of male cancer death in Western countries, and incidence is rising in Asia.7 The strongest risk factor for PCa is a family history, and germline BRCA2 mutations confer the highest risk.8, 9 BRCA2 is critical for the repair of double strand breaks (DSBs) in genomic DNA by homologous recombination (HR).