Studies have shown an association between COMT genotype and symptoms or traits related to panic and anxiety that was specific to women (Domschke et al., 2004; Olsson et al., 2005; Stein, Fallin, Schork, & Gelernter, 2005), while other studies have reported a link between COMT genotype and anxiety endophenotypes or panic disorder in males only (Konishi, Tanii, Otowa, Sasaki, Motomura, et al., 2014; Konishi, Tanii, Otowa, Sasaki, Tochigi, et al., 2014; Lee & Prescott, 2014). Here, COMT is linked to panic disorder.