The transcription factor Yin Yang 1 (YY1) is a member of the GLI-Kruppel family of nuclear proteins that plays an important role in various biological activities, including cell proliferation, angiogenesis and metastasis.6–9 Our previous studies have shown that YY1 is highly expressed in pancreatic cancer, but exerts an inhibitory effect.10 According to the previous ChIP-sequencing results, YY1 binds to the promoter region of tubulin polymerisation-promoting protein (TPPP) and regulates its expression, indicating that TPPP may be involved in the development of pancreatic cancer.11 Here, PROS1 is linked to familial pancreatic carcinoma.