Many prognostic factors have been described for SMZL, such as leukocytosis, thrombocytopenia, elevated β2-microglobulin, anemia, elevated lactate dehydrogenase (LDH), decreased albumin, impaired performance status, advanced age, bone marrow involvement, and histologic transformation [6,7,8,9,10]. The gene discussed is ALB; the disease is Thrombocytopenia.