Finally, live imaging of GFP‐tagged KLK14 in LNCaP cells (Fig. S2B, Video S1) showed that KLK14 transits via endoplasmic reticulum before being specifically localized to the lamellipodia and filopodia of PCa cells, whereas expression of GFP alone was distributed throughout the whole cell (Fig. 2E and Fig. S2C). Here, KLK14 is linked to posterior cortical atrophy.