KLK14 expression was significantly higher in metastasis compared to primary PCa in the three datasets analyzed (Chandran Prostate (Chandran et al., 2007), P = 0.0311; Grasso Prostate (Grasso et al., 2012), P < 0.0001; Taylor Prostate 3 (Taylor et al., 2010), P = 0.0002, Fig. 1B). Here, KLK14 is linked to posterior cortical atrophy.