Specifically, we identified two KLK14 cleavage sites in ST14/matriptase (Arg208 and Arg614) localized between its transmembrane domain and its catalytic site indicating that KLK14 controls the shedding of matriptase which has been previously reported as an important mechanism in invasion of PCa cells (Cheng et al., 2013; Wu et al., 2017). Here, KLK14 is linked to posterior cortical atrophy.