The percentages of high Lp‐PLA2 values (>208.46 mg/L) in the H‐type hypertension group were higher than those in the non‐H‐type hypertension group after adjusting for significantly different risk factors between the two groups, such as gender, diabetes, glucose, and HDL‐C, and higher Lp‐LPA2 levels were independent risk factors for the incidence of ischemic stroke in patients with H‐type hypertension. This evidence concerns the gene LPAR2 and diabetes mellitus.