Numerous reports have demonstrated that inflammatory markers were potential pathogenesis factors, and several biomarkers had been identified as predictors of outcomes for ischemic stroke, such as pro‐BNP, BNP, cortical, and copeptin, which were correlated with short‐term outcomes and mortality rates in AIS, as well as independent short‐term prognostic biomarkers of functional outcomes of AIS.18 Previous reports have demonstrated the association of hyperhomocysteine with ischemic stroke. Here, NPPB is linked to ischemic stroke.