Lp‐PLA2 is a biomarker of inflammation that exists in atherosclerotic plaques as well as in the bloodstream, and it binds to LDL‐C and HDL‐C.7, 9, 10 Lp‐PLA2 within plaques participated in inflammation and increased the rupture of plaques.27 A novel finding of the present study was that patients with ischemic stroke with H‐type hypertension had higher Lp‐PLA2 levels. The gene discussed is PLA2G7; the disease is ischemic stroke.