Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) is a new inflammatory biomarker, which is secreted by monocytes, macrophages, and T cells.7 High Lp‐PLA2 levels have been associated with an increased risk of atherosclerosis and ischemic stroke.8 In the blood circulation, Lp‐PLA2 primarily binds to LDL‐C and HDL‐C.7, 9 Lp‐PLA2 can generate the pro‐inflammatory molecules lysophosphatidylcholine and oxidized free fatty acids by hydrolyzing phospholipids of LDL‐C and HDL‐C, and these pro‐inflammatory molecules promote ischemic stroke.10 The gene discussed is PLA2G7; the disease is ischemic stroke.