Recent studies have shown that excess energy intake and endogenous lipolysis of saturated fatty acids might increase the production of proinflammatory cytokines, including IL-6 and MCP-1 as well as activation of NF-κB signaling pathway, which partly contributed to adipocyte inflammation and obesity [34–36]. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.