These include chronotype (PSME4, ACYP2, PHACTR1, and MSRA), body mass index (PSME4, PAX2, NRXN1, CTNNA2, LRP1B, ADAM23, ADARB1, CPNE4, DGKG, and SV2C), response to chemotherapy in breast cancer hypertensive cases (MSRA and SV2C), and neurocognitive impairment in HIV-1 infection (FAM155A, SH3RF3 and TOX). The gene discussed is TOX; the disease is breast cancer.