These include multiple mental disorders, i.e., autism spectrum disorder, attention deficit-hyperactivity disorder (ADHD), major depressive disorder, and schizophrenia (TCF7L2, NTRK3, GRIN2A and CSMD1), amyotrophic lateral sclerosis (NTRK3, CSMD1, CNTN5, PIEZO2, RNF165 and DOCK4), cerebrospinal fluid clusterin levels (CSMD1, FOXN3 and ABCA13), bipolar disorder and eating disorder (RYR2 and NRG3), copper levels (GRIN2A, FOXN3, CCDC85A and FARS2), optic disc area (CTNNA3, VGLL4 and RARB), and loneliness (CNTN5, MBOAT1 and UTRN). The gene discussed is CLU; the disease is major depressive disorder.