The only T2D variant apart from that near GCKR associated with ACR is that in ARL15, where the ACR-raising allele is associated with higher risk of T2D, but with a much lower odds ratio (1.06 [95% CI: 1.04–1.09)] (19) than many other known T2D variants. This evidence concerns the gene ARL15 and type 2 diabetes mellitus.