Two variants represented known T2D signals (a variant in the ARL15 locus and a variant in the SNX17 locus that is in LD with highly pleiotropic variants at the GCKR locus (r2 > 0.85)), three represented known CAD signals (a variant near KCKN5, one near TRIB1, and one in the intron of CCDC97) and one represented a known blood pressure signal (a variant in HOTTIP). This evidence concerns the gene HOTTIP and type 2 diabetes mellitus.