CUBN and Stroke: Contrary to our hypothesis that CUBN ACR-raising alleles are benign for vascular-related diseases, people above the clinical threshold and carrying ACR-raising alleles at the CUBN locus had a higher frequency of CAD (carriers 11.2% vs non-carriers 10.2%, chi-squared P = 0.005), T2D (carriers 6.7% vs non-carriers 5.7%, chi-squared P < 0.001) and stroke (carriers 3.4% vs non-carriers 2.9%, chi-squared P = 0.006, SupplementaryMaterial, Table S8).