ROC analysis revealed that combined serum ICAM-1 and expression levels to discriminate PCOS from control, the AUC was 0.989 (95% CI 5 0.980–0.997, P < 0.001) with sensitivity = 99.4%, specificity = 85.8%, (Fig. 3c). Here, ICAM1 is linked to polycystic ovary syndrome.