After adjustment for potential confounding factors including age, sex, BMI, hypertension, smoking, total cholesterol, triglyceride, LDL-C, high-density lipoprotein cholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), estimated glomerular filtration rate (eGFR), and prior statin therapy, duration of DM remained predictive for plaque rupture and TCFA (Tables 4, 5). This evidence concerns the gene CRP and hypertensive disorder.