Elevated serum levels of thymic stromal lymphopoietin lead to an increase in the production of proinflammatory cytokines in CD14+CD162+ monocytes, CD14+CD16+ monocytes and CD4+ T cells, which might be correlated with higher mortality of patients with sepsis with hyperleukocytosis or high neutrophil ratio. The gene discussed is CD14; the disease is Sepsis.