Though patients with del(17p) CLL were excluded from the study, 12 ibrutinib-treated patients had TP53 mutation; median PFS was not reached for ibrutinib-treated patients with TP53 mutation or TP53 wild type (HR [95% CI: 0.866 [0.264–2.846]) and the 5-year estimates were 56% and 73%, respectively. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.