TP53 and B-cell chronic lymphocytic leukemia: In patients with high prognostic risk CLL (TP53 mutation, del[11q], and/or unmutated IGHV), OS at 5 years without censoring for crossover to ibrutinib was 84% for ibrutinib and 62% for chlorambucil (HR 0.376 [95% CI: 0.180–0.786]).