PLEC and neoplasm: Recently it was shown that plectin, as part of a plectin-EPLIN (epithelial protein lost in neoplasm)-microtubule complex (in KRASV12 transformed cells), plays an important role in the apical extrusion of KRAS V12 transformed cells from normal epithelial cells and thus activation of the plectin complex could enhance eradication of newly emerging transformed cells from the epithelium42, indicating plectin could be a target for both early cancer prevention as well as CSCs in established cancers.