It is interesting that the decrease of plectin associated lung cancer survival is more significant in non-smokers (HR = 3.2, p = 2.8e−5, Fig. 6 and Supplementary Fig. S7) than that in smokers (HR = 1.9, p = 4.8e−4, Supplementary Fig. S7). This evidence concerns the gene PLEC and lung carcinoma.