In summary, we used a peptoid OBTC combinatorial cell screen to unbiasedly target a ALDH+ subpopulation in a NSCLC which led to the identification of peptoid PCS2, which in turn led to identification of its binding target, plectin which was expressed on the surface of NSCLC tumor cells but not normal lung epithelial cells. Here, LDHA is linked to non-small cell lung carcinoma.