SLC6A5 and hyperekplexia: Although the importance of GlyT2-mediated glycine transport in pathology is known2,6,9 and some regulatory mechanisms of this neuronal transporter have been described, a deeper understanding the molecular regulation of GlyT2 would provide insight into the molecular and cellular basis of glycinergic neurotransmission and potentially lead to identifying new therapeutic targets for Hyperekplexia or chronic pain.