These efforts revealed that multiple cell types from people with DS show transcriptional signatures indicative of constitutive activation of the interferon (IFN) response12, which could be explained by the fact that four of the six IFN receptors (IFNRs) are encoded on chr21: the two Type I IFNR subunits (IFNAR1, IFNAR2), one of the Type II IFNRs (IFNGR2), and IL10RB, which serves both as a Type III IFNR subunit and a subunit of the receptors for interleukin (IL)-10, IL-22, and IL-2614. Here, IFNA1 is linked to Dravet syndrome.