Furthermore, an identical relative order of these mutations can be found in the original study (Leung et al. 2017), which implies an enormous false positive rate in metastatic cells for the mutation in FUS. More precisely, out of 20 single cells (all metastatic) where presence of mutation was reported, 10 needed to be altered 1 → 0 during tumor phylogeny inference, implying a false positive rate of 50% for this mutation. This evidence concerns the gene FUS and neoplasm.