Indeed, in a mouse MC38 colon cancer model sensitive to PD-1/PD-L1 blockade therapy (Homet Moreno et al., 2016), the combination of creatine supplementation and anti–PD-1 treatment generated a significant tumor suppression effect superior to that of each treatment alone (Fig. 6, A and B). The gene discussed is CD274; the disease is malignant colon neoplasm.