CD8A and neoplasm: In particular, the PD-1hiTim-3hiLAG-3hi tumor-infiltrating CD8 T cells, which are considered to be the most “exhausted,” expressed the highest levels of CrT, suggesting that these cells may also benefit the most from creatine supplementation treatment (Fig. S1 K; Nguyen and Ohashi, 2015; Wherry and Kurachi, 2015).