MAPT and Alzheimer disease: We investigated that the ability of oligomeric Aβ to promote tau seeding suggests a specific and plausible mechanism by which extracellular Aβ initiates a deleterious cascade that is unique to AD using several cell-culture models, including FRET-based tau biosensor cells, human neuroblastoma cells, and primary hippocampal neurons from transgenic mice expressing human P301S tau.