Genetic polymorphisms associated with KD susceptibility and resistance to IVIG therapy are documented in the gene encoding inositol-triphosphate 3-kinase C (ITPKC) [4], in the CASP3 gene [5], in the gene encoding ORAI1, a calcium release-activated calcium channel protein 1, with a possible influence on the immune response to EBV infection [6]. This evidence concerns the gene ORAI1 and Epstein-Barr virus infection.