In addition to its potential anti-inflammatory role, it has been described that GPNMB is related to the autophagic-lysosomal pathway, involved in lysosomal stress and in the degradation of cellular debris [68,69].The fact that GPNMB is overexpressed in a variety of neurodegenerative diseases, its key role as anti-inflammatory, and its relation with the autophagic-lysosomal pathway suggest that the normal function of this protein is essential for keeping homeostatic brain status. Here, GPNMB is linked to neurodegenerative disease.