For RDT, Yamamoto et al. showed immunohistochemical analysis of a rat glioma subcutaneous model to reveal that numerous ionized calcium-binding adapter molecule 1 (Iba1)-positive macrophages gathered at the surface and within the subcutaneous tumors after multidose ionizing irradiation in combination with 5-ALA administration [24]. Here, AIF1 is linked to central nervous system cancer.