Abbreviation: CP: Child-Pugh; CTLA4: Cytotoxic T-Lymphocyte Antigen-4; DCR: disease control rate; HCC: hepatocellular carcinoma; mOS: median Overall survival; mPFS: median Progression Free Survival; ORR: overall response rate; PD-1: Programmed death 1; PD-L1: Programmed death-ligand 1; PR: partial response; SD: stable disease; TACE: transarterial chemoembolization; TKI: tyrosine Kinase Inhibitor. The gene discussed is CD274; the disease is hepatocellular carcinoma.