Given the tight correlation between the endothelial and epithelial function in immune response modulation against different cancer types [27,28,29], extensive investigation in HCC patients pinpoint LSECs as immune tolerance inducer of CD8-positive T cells to tumor-associated antigens, inducing T-regs, and also increase PD-L1 expression which correlate with recurrence after surgery and poor prognosis in advanced HCC (Figure 1) [30]. Here, CD274 is linked to hepatocellular carcinoma.