SOD1 and amyotrophic lateral sclerosis: Given the established in-trans effects of astrocytes on MN death in ALS [5,6,7,13,58,59], and the possible involvement of astrocytic Ca2+ dysregulation in such a process [11,12,13], here we carried out a comparative analysis of SOCE in primary spinal astrocytes isolated from newborn hSOD1(G93A) and hSOD1(WT) Tg mice by means of locally targeted GECIs.