Considering the well-recognized role of astrocytes in ALS pathogenesis, and that the control of Ca2+ homeostasis is fundamental for proper astrocyte functions [18,19,20,21], we undertook a comparative study of Ca2+ dynamics in primary spinal astrocytes from newborn hSOD1(G93A) and hSOD1(WT) mice. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.