TARDBP and amyotrophic lateral sclerosis: Most of ALS cases (90%) are sporadic, but the disease also occurs on inheritable grounds (familial ALS, fALS), with the majority of fALS associated with mutations in the C9orf72, TDP-43 (TAR DNA-binding protein 43), RNA-binding protein FUS/TLS (Fused in Sarcoma/Translocated in Sarcoma) or superoxide dismutase 1 (SOD1) genes [3].