SOD1 and amyotrophic lateral sclerosis: The precise mechanisms leading to such a chronic unbalance of cell Ca2+ homeostasis in hSOD1(G93A) astrocytes, which may weaken ALS astrocytes themselves and contribute to their long-term degeneration [12], as well as perturb (Ca2+-dependent) astrocyte-MN cross-talk [5,11], remain to be determined and deserve further investigation.