In humans, chronic HCMV infection also leaves stable imprints on the NK cell repertoire [69], principally through expansion of NKG2C+ NK cells that co-express self-specific inhibitory KIR, the inhibitory LILRB1 receptor and exhibit decreased expression of the activating receptor NKp30 [42,63,70]. Here, KLRC2 is linked to cytomegalovirus infection.