However, unlike Ly49H in mice, NKG2C is dispensable for the generation of adaptive NK cells in response to HCMV infection: individuals carrying a homozygous deletion of NKG2C that prevents protein expression still mount adaptive NK cell responses that exhibit a phenotypic, functional and epigenetic profile of adaptive NK cells [72,73,74]. This evidence concerns the gene KLRC2 and cytomegalovirus infection.