Interestingly, CAF-1/p60 expression levels are significantly correlated with the biological aggressiveness of tumours, metastasizing behaviour and worse prognosis in breast, oral, prostate, laryngeal and salivary gland carcinomas, as well as in skin melanoma [20,21,22,23,24,25], suggesting for this protein a promising role as a new sensible prognostic marker, apparently unrelated to their histogenesis. The gene discussed is CHAF1B; the disease is neoplasm.