To investigate the functional role of the CAF-1/p60 and p150 subunits in HNSCC, we evaluated a Tissue microarray (TMA) case study (total number of cases N = 154) of non-oropharyngeal (OSCC) (N = 112) and oropharyngeal squamous cell carcinomas (OPSCC) (N = 42), the latter tested for the presence of the HPV virus (HPV+ OPSCC N = 8). The gene discussed is CHAF1B; the disease is oropharynx squamous cell carcinoma.