These results indicate that, regardless of the prognostic meaning of the expression of the two markers, the pharmacological depletion of CAF-1 complex’s function, combined to PARP-inhibitors and/or radiotherapy, could represent a valid therapeutic strategy for squamous cell carcinomas of head and neck region, by the mean of a synthetic lethality mechanism. The gene discussed is PARP1; the disease is squamous cell carcinoma.