TNF and obesity due to melanocortin 4 receptor deficiency: Interestingly, another member of the TNF-α protein family, the TNF-related apoptosis-inducing ligand (TRAIL-R2), which has been recently involved in obesity and AT inflammation [133], is targeted by let-7c, thus the let-7c-mediated anti-inflammatory action of HT might be even wider and deserves further investigation.