MMP2 and obesity due to melanocortin 4 receptor deficiency: We also observed that HT decreased the inflammatory induction of active players—and potential targets—of obesity-related remodeling, including the proteolytic enzyme MMP-2 (gelatinase A), the proangiogenic VEGF-A, as well as the pro-inflammatory enzyme COX-2 and its eicosanoid product PGE2.