PTGS2 and metabolic syndrome: Collectively, these data corroborate and further expand the human reports of inhibitory effects by polyphenol-rich EVOO consumption, within or out of the frame of the Mediterranean diet, on plasma levels [93,94,95] as well as monocyte [93,96,97,98,99] and endothelial cell [100] gene expression of pro-inflammatory biomarkers, such as cytokines, chemokines, adhesion molecules (e.g., IL-1β, IL-6, MCP-1, sICAM-1, COX-2, MMPs) in healthy subjects and in people at high CV risk including overweight/obese or metabolic syndrome subjects.