TNF and obesity due to melanocortin 4 receptor deficiency: Besides reducing cytokine/chemokine gene expression in inflamed adipocytes, and in line with its ability to dampen inflammatory adhesion molecule expression in other cells types such as endothelial cells [74], HT could attenuate the TNF-α-stimulated mRNA and protein expression of ICAM-1 in adipocytes, thus targeting another key event in the initiation and maintenance of the inflammatory cascade in obesity.