CXCL10 and obesity due to melanocortin 4 receptor deficiency: CXCL-10 is produced by mature human adipocytes from various depots, with a positive correlation with body mass index (BMI), visceral adiposity, other parameters of obesity and the risk of T2DM [60], and has also been implicated in the pathogenesis of atherosclerosis as well as obesity-related inflammation [61].