Previous studies found that EVOO polyphenols enhanced NO by activating eNOS in the endothelium, decreasing plasma asymmetric dimethylarginine (ADMA) (an inhibitor of NO synthesis), in concomitance with improvement in vascular reactivity, reduced markers of oxidative stress and vascular inflammation (oxidized LDL, adhesion molecules, CRP, etc.), that impairs NO synthesis and bioavailability [108,109,110,111]. The gene discussed is NOS3; the disease is inflammatory response.