Considering the increased adenosine concentration and increased A2BAR expression in the tumor microenvironment [17,31,100] together with the high expression levels of both A2BAR and DPP4 in macrophages and dendritic cells, growing evidence suggests a critical role of A2BAR together with CD39 and CD73 in modulating cancer progression at least in part via immune suppression. Here, NT5E is linked to neoplasm.