CD274 and neoplasm: Univariate cox regression analysis, including gender, age, histology, pathological grade, tumor stage, lymph node stage, metastasis stage, TNM stage, tumor size, total lymph node number, positive lymph node number, PD-L1 expression, and CD8+ TIL infiltrate was performed for the assessment of their prognostic value, which revealed that age (p = 0.004), tumor stage (p = 0.039), lymph node stage (p < 0.0001), TNM stage (p < 0.000), positive lymph node number (p = 0.001), PD-L1 expression (p = 0.032) and CD8+ TIL infiltrate (p = 0.009) were significant (Figure 3A).