Laird et al. showed that heterozygotic mice with null mutation of Dnmt1, when treated with specific inhibitors of DNA methylation, such as 5-aza-2′-deoxycytidine (5-aza-dC) significantly reduced tumor formation in Apc Min+/− mice (Takebayashi et al. 2007). Here, DNMT1 is linked to neoplasm.