Apart from oncogenic Ras activation, phosphatidylinositol 3-kinase (PI3-kinase) and phosphatase and tensin homolog (PTEN) mutations found in cancer (Chalhoub & Baker 2009) may also potentiate macropinocytosis as an adaptation to limiting nutrient availability (DeBerardinis & Chandel 2016, Cluntun et al. 2017, Recouvreux & Commisso 2017). This evidence concerns the gene PTEN and cancer.