In a noteworthy study, Albrengues et al. demonstrated that an epigenetic switch involving the leukemia-inducible factor (LIF), a proinflammatory cytokine of IL-6 class secreted by cancer cells, reprograms human head and neck CAF into a state that supported cancer cell invasion via extracellular matrix (ECM) remodeling (Albrengues et al. 2015). The gene discussed is LIF; the disease is cancer.