The E2F1 transcription factor is overexpressed in numerous human cancers, including lung, breast, and hepatocellular carcinomas, as well as Sporadic Burkitt Lymphomas (Eymin et al., 2001, Ladu et al., 2008, Molina-Privado et al., 2009, Zhang et al., 2000). The gene discussed is E2F1; the disease is cancer.