The E2F1 transcription factor is overexpressed in numerous human cancers, including lung, breast, and hepatocellular carcinomas, as well as Sporadic Burkitt Lymphomas (Eymin et al., 2001, Ladu et al., 2008, Molina-Privado et al., 2009, Zhang et al., 2000). Here, E2F1 is linked to hepatocellular carcinoma.