PTPN11 and hypertensive disorder: Additionally, gene functional annotation of PTPN11/ATXN2 highlights another subnetwork around hemostasis pathways, including platelet activation, aggregation, and sensitization (activated by LDL-c) [28], and these may be relevant to the observed association with hypertension and heart diseases; but how this gene influences serum urate level has not yet been clearly demonstrated.