PTPN11 and familial hypercholesterolemia: The effects of pleiotropic loci (mapped with genes) on serum urate level against their effects on four representative disease outcomes were plotted in S1 Fig, in which the two urate transporter genes (SLC2A9 and ABCG2) are recognised as the leading loci driving the association with gout, the GCKR gene is the leading locus driving the association with hypercholesterolemia, and the PTPN11/ATXN2 gene is the leading locus driving the association with hypertension and ischemic heart diseases.