BAG1 and nonpapillary renal cell carcinoma: Our results indicated that high expression of BAG1 increased the resistance of ccRCC cell lines to drugs such as Bortezomib, Idelalisib, Shikonin, YM201636, Cabozantinib, and NG-25 (p < 0.05), and increased sensitivity of ccRCC cell lines to other drugs such as Erlotinib, AZ628, Lapatinib, A-770041, and HG-5-88-01(p < 0.05; Figure 9A).