Nevertheless, the higher CTX level in the control group indicates reduced boneresorption in both mild and severe AIS groups; therefore, the higher serum osteocalcinlevel in mild AIS might be more likely to be attributed to increased osteoblastactivity, and the drop of serum osteocalcin and sclerostin levels in severe AIS suggeststhe likelihood of reduced osteoblast and osteocyte activity. The gene discussed is SOST; the disease is androgen insensitivity syndrome.