In summary, the findings in this series of studies demonstrated thepotential link of abnormal osteocyte lacuno-canalicular network structure andfunction to the observed abnormal bone mineralization in AIS, which may shed light onetiopathogenesis of AIS.—Chen, H., Zhang, J., Wang, Y., Cheuk, K.-Y., Hung, A.L. H., Lam, T.-P., Qiu, Y., Feng, J. Q., Lee, W. Y. W., Cheng, J. C. Y. Abnormallacuno-canalicular network and negative correlation between serum osteocalcin andCobb angle indicate abnormal osteocyte function in adolescent idiopathicscoliosis. This evidence concerns the gene BGLAP and androgen insensitivity syndrome.