Endothelial dysfunction identified in clinical practice is managed with modification of cardiovascular risk factors, including weight loss, exercise prescriptions, angiotensin-converting enzyme inhibitors, lowering of low-density lipoprotein levels with statins, hormonal therapies, antioxidants, and smoking cessation.12 In our study, none of the patients received specific interventions beyond education and counseling. The gene discussed is ACE; the disease is endothelial dysfunction.