MDM2 and neoplasm: Both MDM2 and CDK4 can be amplified/overexpressed in both ALT/WDLPS and DDLPS; therefore, WDLPS and DDLPS cannot be distinguished based on the amplification and overexpression of MDM2 and CDK4.[21] After the tumor is completely resected, histopathological features can be used to distinguish between ALT/WDLPS and DDLPS.