We demonstrated that hyperglycemia aggravated acute liver injury induced by thioacetamide by promoting liver‐resident macrophage NOD‐like receptor family pyrin domain‐containing 3 protein inflammasome activation via inhibiting autophagy mediated by 5′ AMP activated protein kinase/mammalian target of rapamycin (AMPK/mTOR). The gene discussed is MTOR; the disease is Hyperglycemia.