The possible upregulation of total protein expression and phosphorylation of CREB, via miR‐134‐5p knockdown, most likely led to the synthesis of various plasticity‐related proteins that impose structural changes in the synapses, support synaptic strengthening, and thereby, maintain late LTP and STC (Korte & Schmitz, 2016) in Aβ‐induced AD condition. The gene discussed is CREB1; the disease is Alzheimer disease.