Interestingly, mutations in Crumbs homolog‐1 (CRB1), a protein essential for the integrity of adherens junctions and Müller glia–photoreceptor interactions, are associated with a wide spectrum of retinal dystrophies, including Leber congenital amaurosis (LCA) and early‐onset recessive retinitis pigmentosa (RP) 27, 33. This evidence concerns the gene CRB1 and Leber congenital amaurosis.