RAE1 and neoplasm: Tumor immune surveillance by activated murine γδ T cells has been linked to their surface expression of the C‐type lectin receptor NKG2D, ligands for which Rae‐1 and H‐60 (MICA and MICB in humans) are expressed at the surface of stressed cells.43, 46 In mice, DETCs together with Langerhans cells (epidermal dendritic cells) and tissue‐resident CD8+ memory T cells form a network integrated within the epidermis.53 Upregulation of Rae‐1 by epidermal cells induces activation and remodelling of DETCs from dendritic‐ to round‐shaped cells, leading to a reorganisation of the epidermal architecture.