This is exemplified by the TCR‐mediated recognition of endothelial protein C receptor (EPCR) expressed on CMV‐infected endothelial cells by a γδ T‐cell clone bearing a Vγ4Vδ5 TCR, which required CMV‐induced upregulation of ICAM‐1 by target cells for an optimal response.81 Similar to Vδ2+ cells, Vδ1+ γδ T cells induce tumor cell death through soluble cytotoxic machinery (perforin, granzymes and granulysin) and cytokine secretion (IFN‐γ and TNF). This evidence concerns the gene PRF1 and neoplasm.