Initial studies performed in murine models of cancer have found protective roles for γδ T cells against tumor growth.43, 44 Several mechanisms, through which they mediate their antitumor effects, have been described, including not only direct killing of tumor cells mediated by cytolytic proteins or NKG2D‐dependent mechanisms, but also indirect effects mediated by their production of IFN‐γ, as illustrated in Figure 2. This evidence concerns the gene KLRK1 and neoplasm.